| abstract |
A novel oxazinone derivative represented by general formula (I), which is useful as an antiinflammatory agent, a neutrophile infiltration inhibitor and a serine protease inhibitor, and a pharmaceutically acceptable acid addition salt thereof. In formula (I) A represents the group (a) (wherein W represents a single bond, -O-, -S-, -CH=CH- or -NR9-; V2 represents =CR12- or =N-; and D represents a 5-to 7-membered carbocyclic or heterocyclic ring); X represents a single bond, -O-, -S-, -CO- or -NR15-; Y represents a single bond, -O-, -CH=CH- or -NR16-; Z represents -CH¿2?- or -CO-; I represents an integer of 0 to 4; and R, R?1 to R16¿ represent each hydrogen, lower alkyl, etc. |