| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d642cb421faf12e9be771e2c92c72773 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S436-806 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1845
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01R33-5601
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-085
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-128
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1836
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1863 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R33-28 |
| filingDate |
1992-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77e9e15336c47af8eaeb612034eed9ea |
| publicationDate |
1992-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9217214-A2 |
| titleOfInvention |
Physically and chemically stabilized polyatomic clusters for magnetic resonance image and spectral enhancement |
| abstract |
Improved compositions and methods for selective access to tumor regions (or other regions of abnormal endothelial properties). This capability provides powerful contrast-enhancement agents for nuclear magnetic resonance imaging. A polyatomic complex which includes intramolecular ferromagnetic coupling between metal atoms is associated with a polymer or microsphere carrier matrix which will bind to endothelial determinants. A solution containing this carrier complex is injected into a human (or other) body to be imaged. The carrier complex will preferentially extravasate at locations where the blood vessel walls have increased porosity or microvascular surface changes, and especially at tumor sites. Thus, the changes in relaxation time induced by the presence of the carrier complex will provide a high-gain marker for magnetic resonance imaging. Multiple superparamagnetic polyatomic complexes are described, including novel complexes which include acetate and glycinate bridging ligands with a polyatomic metal-atom-complex core. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9044381-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5482699-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10952965-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0015267-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9618421-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004004786-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9731037-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004112747-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9364443-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6106866-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9514491-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5707604-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3842048-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6355224-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8632751-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8722091-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8333959-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9514491-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8986736-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6479033-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5932190-A |
| priorityDate |
1991-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |