abstract |
The present invention provides for a novel mechanism of controlling anti-inflammatory activity in a mammal, including humans. The inhibition of P-glycoprotein mediated transport of Interleukin-1 (IL-1) from cells, by an inhibitor of the mdr P-glycoprotein, provides for treatment of indications in which excessive extracellular IL-1 activity is implicated. Such activity has been implicated in such disease as rheumatoid arthritis and osteoarthritis. |