| abstract |
The invention concerns a method of producing cross-linked collagen particles with diameters in the micrometer and nanometer range. A dispersion or solution of collagen in water, with emulsifiers added, is finely mixed with an organic phase, which is not miscible with water, to form a water/organic emulsion. A cross-linking agent is then added and the collagen cross-linked at the droplet boundary surface, the collagen particles thus produced being isolated by separating off the organic phase and washing. |