| abstract |
Novel antibacterial compounds are disclosed having formula (I) as well as pharmaceutically acceptable salts, esters, amide and prodrugs thereof, wherein R?1 is selected from the group consisting of (a) lower alkyl, (b) halo(lower alkyl), (c) lower alkyl(alkynyl), (d) lower cycloalkyl, (e) lower alkylamino, (f) nitrogen-containing aromatic heterocycle, (g) bicyclic alkyl and (h) phenyl; R?2 is selected from the group consisting of hydrogen, lower alkyl, a pharmaceutically acceptable cation, and a prodrug ester group; R?3 and R?4 are independently selected from the group consisting of hydrogen, halogen, amino, and lower alkyl; R?5 is either a nitrogen-containing heterocycle or a nitrogen-containing spiro-bicyclic-heterocycle; and A is N or C-R?6, wherein R?6 is selected from the group consisting of hydrogen, halogen, lower alkyl, and lower alkoxy, or R?1 and R?6 taken together with the atoms to which they are attached form a 6-membered ring which may contain an oxygen or sulfur atom and which may be substituted with lower alkyl; as well as pharmaceutical compositions comprising such novel compounds and the therapeutic use thereof. |