| abstract |
The invention provides compounds of general formula (I) or a physiologically acceptable salt, solvate or metabolically labile ester thereof wherein Q represents an oxygen or sulphur atom; R1 represents a hydrogen atom or a halogen atom or a group selected from C¿1-6?alkyl, C2-6alkenyl, fluoroC1-6alkyl, -CHO, -CO2H, C1-6alkoxy, or -COR?2¿; Ar represents the group (a); R2 represents a group selected from C¿1-6?alkyl, C2-6alkenyl, C1-6alkoxy or the group -NR?12R13; R3¿ represents a group selected from -CO¿2?H, -NHSO2CF3 or a C-linked tetrazolyl group; R?4 and R5¿, which may be the same or different, each independently represent a hydrogen atom or a halogen atom or a C¿1-6?alkyl group; Het represents the group (b); X represents N or CH; Y represents N or CR?7¿; Z represents N or CR7; R6 represents a hydrogen atom or a C¿1-6?alkyl, C2-6alkenyl or a C1-6alkylthio group; R?7¿ represents a halogen atom or a group selected from cyano, nitro, C¿1-6?alkyl, C2-6alkenyl, fluoroC1-6alkyl, -(CH2)mR?8¿, -(CH¿2)nCOR?9, or -(CH¿2?)pNR?10COR11; R8¿ represents a hydroxy or C¿1-6?alkoxy group; R?9¿ represents a hydrogen atom or a group selected from hydroxy, C¿1-6?alkyl, C1-6alkoxy, phenyl, phenoxy or the group -NR?12R13; R10¿ represents a hydrogen atom or a C¿1-6?alkyl group; R?11¿ represents a hydrogen atom or a group selected from C¿1-6?alkyl, C1-6alkoxy, phenyl, phenoxy or the group -NR?12R13; R12 and R13¿, which may be the same or different, each independently represent a hydrogen atom or a C¿1-4?alkyl group or -NR?12R13¿ forms a saturated heterocyclic ring which has 5 or 6 ring members and may optionally contain in the ring one oxygen atom; m represents an integer from 1 to 4; n represents zero or an integer from 1 to 4; and p represents an integer from 1 to 4; with the proviso that at least one of X, Y and Z is a nitrogen atom, and with the further proviso that when X is N at least one of Y and Z is N and when Y is N at least one of X and Z is N. The compounds may be used in the treatment or prophylaxis of hypertension and diseases associated with cognitive disorders. |