| abstract |
A pyrazine derivative which inhibits glutamate receptor, represented by general formula (Ia) wherein Z represents C or N, provided that two Zs are not N atoms at the same time; R?1 represents (1a) wherein X represents N or R?8C, R?6 represents H or alkyl, and R?7 and R?8 represent each H, alkyl, nitro or phenyl, or alternatively R?7 and R?8 are combined together to represent butadienylene or 1,4-butylene; R?2 and R?3 represent each H, F, cyano, acyl, nitro, alkyl, morpholino or R?1; R?4 and R?5 represent each H, hydroxy, alkyl, cycloalkyl, heterocycle, pherryl or Y-substituted alkyl; Y represents hydroxy, acyloxy, F-substituted methyl, cycloalkyl, tetrahydrofuryl, carboxyl, alkoxy carbonyl or NR?9R?10; and R?9 and R?10 represent H or alkyl, or alternatively R?9 and R?10 are combined together to represent a 5- or 6-membered cyclic group which may contain oxygen atom(s). |