| abstract |
This invention is therapeutically useful 2-aminotetralins and pharmaceutically acceptable acid addition salts thereof of formula (I), wherein R is hydrogen or halogen, wherein R1 is hydrogen, OR4, SR4, CONR5R6, CN, het, C(O)het, CF3, SO2NR5R6, 5-oxazolyl, CSNR5R6, OSO2CF3, wherein R2 and R3 are independently hydrogen, alkyl, alkenyl, alkynyl, (CH2)m-cycloalkyl, (CH2)m-cycloalkenyl, (CH2)m-aryl, (CH2)m-CO2R4, (CH2)m-OR4, wherein R4, R5 and R6 are independently hydrogen, alkyl, alkenyl, cycloalkyl, and wherein X is (CH2)n, m = 0-4, n = 4-8, p = 0,1. These compounds are useful to treat central nervous system disorders, hypertension, diabetes, sexual impotency and to control appetite. |