| abstract |
A pyrimidine derivative represented by general formula (I), a pharmaceutically acceptable salt thereof, and an androgen inhibitor comprising the same having an excellent effect of treating prostatic hyperplasia, female hypertrichosis, and male baldness or pimple: wherein R?1 represents hydrogen or hydroxyl; R?2 represents hydrogen, lower alkoxycarbonyl, lower alkoxy, halogen, lower alkyl, C3? to C8? cycloalkyl, lower alkoxycarbonyl lower alkyl, carboxyl, carboxylated lower alkyl, CONHR, cyano, phenyl, phenylated lower alkyl, lower alkanoyloxy lower alkyl, benzoyl, lower alkanoyl or hydroxylated lower alkyl; R?3 represents hydrogen, hydroxy, lower alkyl, C3? to C8? cycloalkyl, halogenated lower alkyl or phenyl; R?4 represents hydrogen, lower alkyl or lower alkoxy, R?5 represents hydrogen, lower alkyl, lower alkoxy lower alkyl or halogenated lower alkyl. |