| abstract |
Substituted 4,5-diaryl-1-carboxyalkylimidazoles, of structure (I), in which each group Ar is the same or different and is optionally substituted phenyl or optionally substituted heteroaryl or, when both groups Ar are phenyl they can be linked by a bond; R is hydrogen, alkyl, alkoxy, alkyl, optionally substituted phenyl, phenyl alkyl in which the phenyl group is optionally substituted, alkylCHO or alkylCH(OR1)(OR2) in which each group R?1 and R2¿ is alkyl, or together form an ethane 1,2-diyl or propane 1,3-diyl group; n is 2 to 6 and m is 0 to 6; R?3, R4, R5 and R6¿ are the same or different and are each hydrogen or alkyl; AB is a bond, -C=C-, -CH=CH-, S, O, SPh or OPh; and X is CO¿2?H or a group hydrolysable to CO2H, 5-tetrazolyl, SO3H, P(O)(OR)2, P(O)(OH)2, or P(O)(R)(OR) in which R is hydrogen or alkyl, or a pharmaceutically acceptable salt thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, inter alia, in the treatment of cardiovascular disorders. |