| abstract |
Chimeric HIV-1-neutralizing immunoglobulins, made up of a non-human antigen binding region and a human constant region, are discribed. One particularly good HIV-1-neutralizing antibody is designated CGP 47 439. These antibodies are useful for immunotherapy of AIDS, AIDS related complex (ARC), and passive immunization of infected but asymptomatic individuals, seronegative persons in high risk groups, or persons who have been exposed to HIV-1 and are at risk of infection. |