| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59c6a921f33fe0adc58c2b6177184515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21cbff64022f95c237c0bd3ec8656ca |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-18 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-13 |
| filingDate |
1990-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_702a6f03a6b3ff3ffb7ca963bff67c91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4cd71a47e7d66ba8aa18038b76efdab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9f8e5165845d1dbf669c188b2375108 |
| publicationDate |
1991-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9110427-A2 |
| titleOfInvention |
The effect of transglutaminase inhibition on microfilariae development and macrofilariae viability |
| abstract |
A method is described for inhibiting maturation and production of microfilariae in adult filarial nematodes. Inhibition of transglutaminase or transglutaminase mediated reactions utilizing a transglutaminase inhibitor to block the maturation and production of microfilaria by the adult organism, as well as kill the adult filarial organism. Experiments applying this method to several Brugia filarial infections, including Brugia malayi, were successful. Higher concentration of transglutaminase inhibitor prove the described filaricidal effect of the adult organism existing independent of a host or existing within a host organism. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9824887-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9318760-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6383774-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9804245-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9824887-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5885982-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-674828-B2 |
| priorityDate |
1990-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |