| abstract |
A quinoline derivative of formula (I), wherein each phenyl ring of A and B can have one or more substituents; X is (II) (R1 is a hydrogen atom, a lower alkyl group or a lower alkoxy group) or (III) (R2 is a hydrogen atom or a lower alkyl group); Y is -(CH¿2?)m-(m is 0, 1 or 2) or -CH=CH-, Z is a group of formulae (IV), (V) or (VI), wherein each phenyl ring of C and D can have one or more substituents, R?3 and R4¿ are each a hydrogen or halogen atom, or a lower alkyl, lower alkoxy, lower acyloxy, lower alkoxycarbonyloxy, N,N-di-lower alkylcarbamoyloxy, optionally esterified carboxy or hydroxyl group, R5 is a halogen atom, or a lower alkyl, lower alkoxy, lower acyloxy, lower alkoxycarbonyloxy, N,N-di-lower alkylcarbamoyloxy, optionally esterified carboxy or hydroxyl group, R?6 and R7¿ are each a hydrogen atom or a lower alkyl group, and n, o and p are each 1 or 2; l is 0 or 1; or its salt, which is useful as a drug for atherosclerosis. |