http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9109012-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68c213ba9952360f439567152e047b18 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 |
| filingDate | 1990-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ce4afabe6ddeeaedcc43ecb92a966b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98d3b6fb87d424df6b9124ef1eb4d373 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84b85151162da555815d21891d7b3e75 |
| publicationDate | 1991-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9109012-A1 |
| titleOfInvention | Processes for preparing prostaglandins |
| abstract | A process for the preparation of a prostaglandin of formula (I), wherein n is 1, 2, 3 or 4, R1? and R2?, independently of each other, are alkyl, OH, alkoxy, ketone, halogen, hydrogen, nitro, amino or ether, R3? is hydrogen, alkyl, haloalkyl or carboxyalkyl, R4? is hydrogen, alkyl or haloalkyl, R5? is hydrogen, alkyl or haloalkyl comprising (a) reacting an S-enone of formula (II) with a compound of formula (III) in the presence of a Lewis acid, wherein n is 1, 2, 3 or 4, R6?, R7? and R8? are alkyl or any two or three combined are cycloalkyl or aryl, R9?, R10? and R11? are alkyl or any two or three combined are cycloalkyl or aryl, R12? is hydrogen or alkyl, (b) reacting the compound from (a) with an aldehyde in the presence of TiCl4?, (c) acetylating the compound from (b), (d) reacting the compound from (c) with Pd(MeCN)2?Cl2?, (e) reducing the compound from (d), (f) acetylating the compound from (e), (g) reacting the compound from (f) with TBAF, (h) reacting the compound from (g) with DIBAH and (i) reacting the compound from (h) with a Wittig reagent. |
| priorityDate | 1989-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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