http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9108775-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2613944636ab2fdf3f83ef2d4b304f0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6889 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 1990-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d57dea33bd0cea4b57703b8fcaf4599 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3d8572e3632258a5794d28203255f87 |
| publicationDate | 1991-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9108775-A3 |
| titleOfInvention | Maleic anhydride derivatives used as conjugation agents of anti-tumor agents on desired carriers |
| abstract | The present invention relates to anti-tumor-conjugation agent-protein compounds of general formula (I), wherein R1 and R2 are each independently members selected from the group consisting of hydrogen atom, C1-4 alkyl, C1-4 alkoxy, C1-6 carboxyalkyl, phenyl, and phenyl substituted by at least one of hydroxy, halogen, lower alkyl, lower alkoxy, or nitro, with the proviso that R1 and R2 cannot be simultaneously a hydrogen atom, and when one of R1 or R2 is a hydrogen atom, the other one cannot be -CH2COOH; A is the residue of an anti-tumor agent containing at least one amino group available to form an amide bound; and B is a member selected from the group consisting of hydroxy; a radical of general formula (IIa): -X-R3, wherein X is O, S or Se; and R3 is phenyl; phenyl substituted by at least one of hydroxy, halogen, lower alkyl, lower alkoxy, nitro or cyano; SO2-alkyl; azobenzene; azobenzene substituted by at least one of hydroxy, halogen, lower alkyl, lower alkoxy, nitro or cyano; isoquinoline; piperidine; naphthalene; pyridine; keto pyridine; benzotriazole substituted by at least one of hydroxy, halogen, lower alkyl, lower alkoxy, nitro or cyano; cyclic imides containing 5 to 10 atoms; cyclic imides containing 5 to 10 atoms substituted by at least one of hydroxy, halogen, lower alkyl, lower alkoxy, nitro, cyano, phenyl, phenyl substituted by at least one of hydroxy, halogen, lower alkyl, lower alkoxy, nitro or cyano; phthalimide; phthalimide substituted by at least one of hydroxy, halogen, lower alkyl, lower alkoxy, nitro or cyano; C2-4 alkenyl; C2-4 alkenyl substituted by at least one of hydroxy, halogen, lower alkyl, lower alkoxy, phenyl, nitro or cyano; (a); a radical of the general formula (IIb): -O-NH-CO-R4 wherein R4 is a lower alkyl; lower alkoxy; phenyl; phenyl substituted by at least one of hydroxy, halogen, lower alkyl, lower alkoxy, nitro or cyano; and a free ε-lysine containing residue selected from a peptide or a protein. |
| priorityDate | 1989-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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