| abstract |
This invention relates to compounds having pharmacological activity, processes for their preparation, compositions containing them and methods of treatment involving their use. In its broadest aspect, the invention is concerned with compounds, having general formula (I) in which R1 represents an alkyl C¿1-18? group optionally substituted by an aryl group or hydroxy or a cycloalkyl C3-6 group, R?2¿ represents an alkyl C¿1-18? group optionally substituted by an aryl group, or R?2¿ represents a group -CH¿2¿-X-R4 wherein X represents O or S, and R4 represents hydrogen, an aryl group, or an alkyl or alkenyl C¿1-18? group optionally substituted by an aryl group, R?3¿ represents OH, alkoxy C¿1-6? or -NHR?31¿, wherein R31 represents hydrogen, alkyl C¿1-6?, OH or alkoxy C1-6 optionally substituted by an aryl group, R?5¿ represents hydrogen, an aryl group or an alkyl or alkenyl C¿1-18? group optionally substituted by an aryl group, n represents 0, 1, 2 or 3, p represents 0, 1 or 2, q represents 0 or 1, Y represents -CHR?6¿-, -CH=CH-, O or S, in which R6 represents hydrogen, an aryl group or an alkyl or alkenyl C¿1-18? group optionally substituted by an aryl group, and pharmaceutically acceptable derivates thereof. |