| abstract |
Compounds of general formula (I) and their isomeric and racemic forms: characterized in that n is 0 or 1; A is oxygen, sulphur, C=O, CH2, CF2, CD2, CDH, CHOH, CHX wherein X is fluorine, chlorine, bromine or iodine; G is oxygen, sulphur, CH2 or CX3X4 wherein X3 and X4 are the same or different and each is fluorine, chlorine or bromine; X1 and X2 are the same or different and each is hydrogen or fluorine, chlorine or bromine; and when n is O, X1 and X2 may also be methyl groups; R1 is hydrogen, deuterium, CN, C=CH, fluorine, chlorine or bromine and R6 is hydrogen or deuterium; or R1 and R6 may optionally form =O, or (a) in formula (I) may be (b) or (c), R2 is oxygen, or both H and OH together, or N-OR8 wherein R8 is hydrogen or lower alkyl which is optionally substituted with one or more halo groups; R3 is a halo group, or a lower alkyl, lower alkoxy or lower alkylthio group, in each of which the alkyl group is optionally substituted with one or more halo groups; R4 is hydrogen or a halo or lower alkyl group; or R3 and R4 may optionally form a methylenedioxy bridge which is optionally mono- or di-substituted with fluorine; R5 is hydrogen, OH, lower alkoxy, SH, or lower thioalkyl, fluorine, chlorine, bromine or iodine; R7 is H2, HD, D2 or oxygen. R9 is H, lower alkoxy or lower alkylthio. |