| abstract |
HIV-1 mutant constructs which include a mutation in a nucleotide sequence which is present in wild-type HIV-1, in which it is critical in packaging HIV-1, as well as HIV-1 mutant expression products and HIV mutant viral particles, which are non-infectious. Vaccines which are HIV-1 mutant constructs or HIV-1 mutant expression products, as well as a method if immunizing an individual, comprising administering the vaccine in an appropriate amount. |