| abstract |
A pharmaceutical solution comprising 0.1 to 6.0 % w/w sodium cromoglycate, 0.1 to 2.0 % w/w carbomer, and sufficient quantity of an inorganic base to confer on the solution a pH of from 5.0 to 6.8, the solution containing no amino acids possesses advantageous properties, particularly for ophthalmic use. The solution preferably contains less than 1.5 %, more preferably less than 1.0 %, and more than 0.6 %, e.g. about 0.8 % w/w carbomer. The solution preferably contains more than 1.0 %, e.g. 2 % w/w, and more preferably more than 3 %, e.g. 4 % w/w, of sodium cromoglycate. The concentration of sodium cromoglycate in the solution is preferably less than 5 % w/w. The preferred inorganic base is sodium hydroxide at a concentration of 0.15 to 0.3 % w/w. Also described are processes for the preparation of the solution and methods of treatment involving its use. |