| abstract |
Pharmaceutically active agents are formulated with a bile salt and at least one additional component of bile. The bile salt and additional component may be provided as a naturally occurring bile mix, such as a methanolic extract of animal (for example, ox) bile. A lymphatic absorption promoter such as oleic acid or glycerol mono-oleate may also be present. Pharmaceuticals formulated in this way can benefit from enhanced bioavailability, particularly as hepatic first-pass metabolism is reduced. NSAIDs and cardiovascular agents are particularly suitable for formulation by means of the invention. |