| abstract |
The invention relates to new sulfonamides derived from benzocyclic or benzoheterocyclics and their derivatives of general formula (I), in which R represents a light alkyl radical of 1 to 9 C, linear or branched; a phenyl radical substituted or not by one or several groups: a light alkyl branched or not, having 1 to 4 C, halogeno, alkyloxy, nitro, amino, dialkylamino, CF3?; a naphthalene substituted or not; a thiophenyl radical; R1? represents a lower alkyl branched or not, a benzyl; R2? represents a hydrogen, a lower alkyl group branched or not. A phenyl group substituted or not, an arylalkyl group; R3? represents a hydrogen or a lower alkyl, branched or not (1 to 6 C); X represents a divalent fonctional radical chosen from the following : -CH2?-; -CH-OR4?; -C=O; -C=N-OR4?; and $g(a) with R4?=H or Me, with -X- where X is different from -CH2?- when -A- represents divalent radicals a, b, d, and e below. -A- represents a benzocyclic or benzoheterocyclic bivalent radical chosen from the compounds (a) to (j); n can take the values of 1 to 4 inclusive; as well as the therapeutically acceptable, organic or mineral salts (R3?=H), the pure isomers or diastereoisomers or their mixture and all the pharmaceutical compositions of formula (I) with other active principles. Said invention relates to the application of (I) as medication and to the preparation processes. |