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filingDate 1990-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c37a0697eeebbfed57709b26c3ae9635
publicationDate 1990-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-9011527-A1
titleOfInvention A stable hemoglobin reference solution
abstract A stable reference solution for calibrating and monitoring blood gas instrumentation is disclosed. The solution comprises an aqueous mixture containing a hemoglobin solution derived from a mammalian source which comprises at least about 95 % reduced hemoglobin. The solution additionally contains a bicarbonate buffer and a metal catalyzed methemoglobin reducing system and an organic buffer. To provide a control element having a variety of properties similar to fresh, whole, human blood, the reference solution is stored in a sealed ampule under an inert atmosphere containing CO2 until just prior to use. The ampule is subsequently opened and the solution is equilibrated with a gas mixture having components which provide gasses in a physiological range to the solution. The solution is characterized by exhibiting properties similar to fresh blood subsequent to equilibration and an extended storage life prior to equilibration.
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priorityDate 1989-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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