| abstract |
The present invention provides immobilized cytokines comprising cytokines bound to a solid, preferably biologically inert, support. The bound cytokine, for example IL-2, retains comparable biological activity when bound to the support. Accordingly, the bound cytokine is able to be utilized repeatedly and/or in significantly smaller quantities, as compared to an individual soluble cytokine. Cytokines of the present invention include, but are not limited to, IL-1-alpha, IL-1 beta, rIL-2, IL-2, IL-3, IL-4, IL-6, MuGMCSF, HuGMCSF, HuGCSF, HuEPO, alpha-interferon, gamma-interferon, TNF-alpha, HuILGF-I, HuILGF-II, FGFb, TGF-beta-II, HuEGF, HuPDGF. |