| abstract |
Mammalian pituitary tissues contain newly discovered antiproliferation factor that inhibits in vitro cellular proliferation of lymphoid, neuroendocrine and neural cells but not of fibroblast or endothelial cells. The present invention is directed to this antiproliferation factor which has been named suppressin and is a protein of Mr 63,000, sensitive to reduction and has a pI of 8.1. Suppressin is provided as a cell free preparation or in homogeneous form. The invention provides methods to purify suppressin, antibodies against suppressin and their use in recombinant DNA molecules encoding suppressin, and pharmaceutical compositions for inducing regression or inhibiting growth of tumor or cancer cells and autoimmune diseases. |