| abstract |
Complexes of the general formula [R1(CH2)mC(O)CR?3C(O)R2]¿2+nMX2-n, wherein M denotes tin, titanium, zirconium or hafnium, R1 denotes hydrogen or a phenyl radical, it being possible for the phenyl radical to be monosubstituted or polysubstituted by fluorine, chlorine, bromine, nitro, C¿1?-C4-alkyl, C1-C4-alkoxy or trifluoromethyl, R?2¿ denotes methyl or R1, with the exception of hydrogen, R3 denotes hydrogen or chlorine, X denotes fluorine, chlorine or bromine, but not fluorine if M denotes zirconium or hafnium, m denotes the number 1 or 0, or, if R1 denotes hydrogen, the number 1 and n denotes the number 0, or, if M denotes zirconium or hafnium, the number 1 or 0, exhibit a cytostatic activity which is comparable to that of cisplatin and are less toxic than cisplatin. They are suitable for the production of medicaments having an antineoplastic action. |