| abstract |
New 2',3'-dideoxyribofuranosides with a basic part substituted by purine, pyrazolo[3,4-d]pyrimidine and triazolo[4,5-d]pyrimidine and process for producing them. The process is based on the enzymatic transfer of a 2,3-dideoxyribofuranosyl residue of a suitable 2',3'-dideoxyriboside to an acceptor base. The reactions are brought about by the catalytic activity of nucleoside deoxyribosyl transferase obtained from Lactobacillus leichmannii. The 2',3'-dideoxyribofuranosides so obtained possess a significant chemotherapeutic potential, particularly as antiviral agents. |