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filingDate 1989-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09feba50d83d1e7445a8939a48314ca4
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publicationDate 1990-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-9005143-A1
titleOfInvention Anti-thrombins
abstract A polypeptide derived from leeches of the species $i(Hirudinaria manillensis) has the following amino-acid sequence: X-Y-Tyr-Thr-asp-cys-thr-glu-ser-gly-gln-asn-tyr-cys-leu-cys-val-gly-ser-asn-val-cys-gly-glu-gly-asp-asn-cys-asn-D-gln-leu-ser-ser-ser-gly-asn-gln-cys-val-E-gly-glu-gly-thr-pro-F-pro-gln-ser-gln-thr-glu-gly-asp-phe-glu-glu-ile-pro-asp-glu-Z-ile-lys; wherein X indicates any amino acid residue; Y indicates any amino acid residue; Z indicates any amino acid residue; D indicates cys or pro; and E indicates gly or asp or his; F indicates asp, lys or trp; or a pharmaceutically acceptable salt, derivative or bioprecursor thereof. The polypeptide, and fragments thereof, is a specific anti-thrombin useful as a medicament.
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