| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_917d60cea79afd5e75452471d54b9beb |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06 |
| filingDate |
1989-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b791f1aacf40c763620d50852ad1a0d0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04b114794e0b921ce643eed01a2eb3f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a920e0cb356cdfc3fe1817df74bb861
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9191c55970c73639a8381d16308088b5 |
| publicationDate |
1990-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9003978-A1 |
| titleOfInvention |
5-halogeno-3'-fluoro-2',3'-dideoxyuridine compounds and their therapeutic application |
| abstract |
The novel 5-halogeno-3'-fluoro-2',3'-dideoxyuridines particularly FddClUrd, FddBrUrd, FddIUrd and FddFUrd proved antivirally effective in several in vitro systems (i.e. HIV-1 replication in MT4 and HUT-78 cells and HIV-2 replication in MT4 cells). Of these FddUrd derivatives FddClUrd is endowed with the highest selectivity index in vitro, comparable to that AzddThd in MT4 cells. These observations make the members of the 5-halogeno-substituted FddUrd derivatives attractive antivirals agents for the treatment of AIDS, AIDS-related diseases and retroviral diseases including hepatitis B. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7605144-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5070078-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7465734-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7419968-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7462605-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7601703-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6683061-B1 |
| priorityDate |
1988-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |