| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0338a1beca498c5e6ff6a065b628f975
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d9c5ea990eef66780a0df4049d567860
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba101e0cbf602ee1977ebd3a5c09b947 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-142
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-105831 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6876
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-567 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-567
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
1989-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b07751148d1828fdc711d6b97ae1c10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed844f7382eb60bf04782a82261000e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_527a3ac8b990e799be904d9c470727dc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52f07f9f34258bdf78e1c0e32d39def4 |
| publicationDate |
1990-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9002947-A1 |
| titleOfInvention |
Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants |
| abstract |
Method of detecting chronic exposure of an organism to a pollutant, and for evaluating biological damage due to chronic exposure to sublethal levels of pollutants and kits for carrying out the method are disclosed. The methods comprise: (a) sampling at least one organism in order to determine whether it has been chronically exposed to a sublethal concentration of one or more pollutants in its environment, under sampling conditions that do not induce any additional heat shock protein (hsp) response in the organism; (b) obtaining a sample of cells or secretions of said organism, suspected of having elevated levels of heat shock proteins and solubilizing the heat shock proteins in the sample; and (c) measuring the concentration of a heat shock protein selected from hsp 70, hsp 60 and ubiquitin, in said sample. The invention also provides methods for evaluating biological damage due to chronic exposure to a sublethal concentration of one or more pollutants comprising detecting chronic exposure of the organism by the above method and then comparing the measured concentration of hsp to a predetermined standard calibration curve which correlates hsp concentration with physiological impairment of growth or reproductive processes, and kits for carrying out the methods. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5683868-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2940467-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6740521-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0467973-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0467973-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5877398-A |
| priorityDate |
1988-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |