| abstract |
Compositions comprising a compound of formula (I), and optionally a mild stimulant, are effective for suppressing feeding behavior, substance craving, substance abuse, obsessive-compulsive behavior, and for altering macronutrient preference, and its pharmaceutically acceptable acid addition salts, wherein R1 and R3 are each independently H, hydroxyalkyl, alpha-cyanoalkyl, SO3H, SO2NH2, or C(O)R, where R is OH, NH2, lower alkoxy, benzyloxy, or aliphatic amino acyl; R2 is H, lower alkyl, benzyl, succinyl, or C(O)R4, where R4 is H, lower alkyl, hydrocarboxy-lower alkylene, or lower alkoxycarboxy-lower alkylene; and R5, R6, R7, and R8 are each independently H, halo, lower alkyl, hydroxy, lower alkoxy, or two adjacent radicals form methylenedioxy or ethylenedioxy. |