| abstract |
A compound of formula (I) wherein R1? and R2? are independently selected from hydrogen, loweralkyl, cycloalkyl, loweralkenyl, adamantyl, aryl, substituted aryl, heterocyclic group, substituted alkyl, substituted amide, functionalized carbonyl, and nitrogen containing ring wherein R1?, R2? and the adjacent nitrogen atom form a ring; R11? is hydrogen, loweralkyl, or loweralkenyl; R20? is hydrogen, loweralkyl, or loweralkenyl; B is -(CH2?)m?-, substituted alkenylene, -QCH2?- wherein Q is O, S, NH or substituted amino, -CH2?Q- wherein Q is as defined or B is NH; Z is C=O, S(O)2?, or C=S; Ar is a heterocyclic group, aryl or substituted aryl; D is unsubstituted or substituted indol-3-yl, indolin-3-yl or oxindol-3-yl; and m is 0 to 4; or a pharmaceutically acceptable salt thereof. |