| abstract |
Compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein L is NH or O; either R1? is methyl, R2? is hydrogen and R3? is hydrogen; R1? is methyl, R2? is methyl and R3? is hydrogen; or R1?, R2? and R3? are all methyl; or R1? is hydrogen, R2? is isopropyl and R3? is hydrogen; or R1? is hydrogen and R2? and R3? together are -(CH2?)4?-; Z is a group of formulae (a), (b) or (c), wherein n is 2 or 3; p is 1 or 2; q is 1 to 3; r is 1 to 3; and R4? or R5? is C1-7? alkyl, C3-8? cycloalkyl, C3-8? cycloalkyl-C1-2? alkyl or C2-7? alkenyl-C1-4? alkyl; having 5-HT3? receptor antagonist activity, a process and intermediates for their preparation and their use as pharmaceuticals. |