| abstract |
The present invention provides human monoclonal antibodies having the following essential characteristics: (a) exhibiting activity against Rh(D) antigen, but not C, c, E or e antigens of the Rh blood group system; (b) being IgGl proteins; (c) having kappa light chains; (d) being of the allotype Glm (1, 2, 17); (e) exhibiting activity against DV, DTar, DVI and DB variant antigens; and (f) being substantially non-reactive with non-papain treated DIV cells in an indirect antiglobulin test, which may be employed for Rh-typing of red blood cells and passive immunization to prevent haemolytic disease of the newborn. Such a monoclonal antibody is exemplified by the monoclonal antibody of cell line ECACC 86091603 deposited at the European Collection of Animal Cell Cultures, Porton Down, U.K. on 16th September 1987. |