| abstract |
This invention provides novel cyclic hydrocarbons of formula (I), wherein R is selected from the group consisting of CH2=CH-CH2-, HO-CH2CH2CH2-, and CH3; wherein R1 is selected from the group consisting of m-trifluoromethylphenylmethyl, 2-thienylmethyl, and p-aminosulfonylphenylethyl; wherein R2 and R3 are methyl or hydrogen; wherein R4 is hydrogen or -OH; a compound of formula (II), wherein R is (CH3)2NCH2CH2CH2- or NH2CH2CH2CH2-; and pharmacologically acceptable salts thereof; or a compound of formula (III), wherein the dashed line indicates that the 2-3 bond is saturated or unsaturated and, wherein R is hydrogen or methyl. These compounds are useful for inhibiting adverse physiological symptoms associated with phospholipase A2 and for treating hyperglycemia associated diseases such as diabetes and obesity. |