| abstract |
This invention presents novel 2-azetidinone compounds which are useful as antibacterial agents to eradicate or control susceptible microbes of formula (I), wherein R401? and R402? are the same or different and are a) hydrogen, b) (C1?-C12?) alkyl c) (C2?-C8?) alkenyl, d) (C2?-C8?) alkynyl, e) (C3?-C10?) cycloalkyl, f) phenyl optionally substituted with from one to 3 substituents selected from the group consisting of halogen, hydroxy, amino, nitro, (C1?-C4?) alkyl, and (C1?-C4?) alkoxy, g) benzyl optionally substituted with from one to 3 substituents selected from the group consisting of halogen, hydroxy, amino, nitro (C1?-C4?) alkyl, and (C1?-C4?) alkoxy, h) -CH2?-O-CO-CH2?-NHR420?, i) -CH2?-O-CO2?-R430?, j) -CH2?F, or k) -CHF2?; wherein R420? is a) hydrogen, b) -COH, or c) -CO-O-C(CH3?)3?; wherein R430? is (C1?-C8?) alkyl, -(CH2?)2?OC(O)NH2?, -(CH2?)2?Cl, -(CH2?)2?OCH3? or -(CH2?)2?NHCOH; wherein R300? is an acyl group derived from a carboxylic acid; wherein R100? is an optionally substituted heterocyclic moiety. |