http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-8805043-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4f3768dbfdc2796afdffa2a799c10d84 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-451 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 |
| filingDate | 1987-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c92f9d02871bdcbf028da17faec5878a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bf59bb733f90540008416e1b8971a68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e930b27f804c9de41c10626cd92f839d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28ab91f87304986bb6ec76ca3cc723fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_506966656e4bf190d1c6d0171a68508e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_475eb59078f877babf84a417529a19d7 |
| publicationDate | 1988-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-8805043-A1 |
| titleOfInvention | New aralkyl-1,4-dihydropyridines, a method for their preparation and pharmaceutical compositions containing them |
| abstract | 1,4-Dihydropyridines of formula (I), wherein: X is a -CO2?R1?, cyano, nitro, -COCH3? group; R and R1?, that can be the same or different, are a primary, secondary or tertiary, saturated or unsaturated, linear or branched C1?-C6? alkyl group that can be substituted or not by one or more hydroxy, C1?-C7?-monoalkylamino, di-C1?-C7?-alkylamino, benzylamino, C1?-C6?-alkoxy, phenoxy groups optionally substituted by one or more C1?-C6? alkyl, C1?-C6? alkoxy, halo-C1?-C6? alkyl, halo-C1?-C6?-alkoxy, halogen, nitro, cyano, C1?-C6? alkoxycarbonyl, C1?-C6? alkylthio, NHCOR5?, SO2?R6?, C1?-C4?-alkylamino, di(C1?-C4?)alkylamino, hydroxy; R2? is hydrogen; R3? is hydrogen or a hydroxy, -OCOR5?, OSO2?R6?, azide, amino, -NHPO(OR7?)2?, -NHCOR5? group, a C1?-C4?-alkoxy group or a fluorine, chlorine, bromine or iodine atom, a SH group, a SCOR6? or a C1?-C6?-alkylthio, phenylthio or benzylthio group; R4? is an optionally substituted aromatic or an optionally substituted 5- or 6-membered heteroaromatic group, containing one or more heteroatoms selected in the group of N,S,O, wherein the substituent is selected from one or more hydroxy, C1?-C7?-monoalkylamino, di-C1?-C7?-alkylamino, benzylamino, C1?-C6?-alkoxy, phenoxy groups optionally substituted by one or more C1?-C6? alkyl, C1?-C6? alkoxy, halo-C1?-C6? alkyl, halo-C1?-C6?-alkoxy, halogen, nitro, cyano, C1?-C6? alkoxycarbonyl, C1?-C6? alkylthio, NHCOR5?, SO2?R6?, C1?-C4?-alkylamino, di(C1?-C4?)alkylamino, hydroxy; Y is one or more substituents, that can be the same or different, selected in the group of C1?-C4?-alkoxy, halogen, nitro, cyano, C1?-C6?-alkoxycarbonyl, C1?-C6?-alkylthio, halo-C1?-C6?-alkyl, halo-C1?-C6?-alkoxy, NHCOR5? or NHSO2?R6?; R5? is hydrogen or a C1?-C4?-alkyl, thrihalomethyl, C1?-C4?-alkoxy or phenyl group, optionally substituted by one or more nitro, halogen, C1?-C4?-alkyl, C1?-C4?-alkoxy, amino groups; R6? is hydrogen or a C1?-C4?-alkyl, trihalomethyl, phenyl, or p-methylphenyl group; R7? is a C1?-C4?-alkyl group or a phenyl group, are useful as antihypertensive, cytoprotecting or anti-ulcer agents. |
| priorityDate | 1986-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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