| abstract |
Process for the production of 3alpha-hydroxy-prostacyclin intermediates of formula (+)-I, where A is the residue -CH2- or >CH-COOR, B is oxygen or the double-bond residue -O-X-O- with X as a straight or branched-chain alkylene with 1-7 C atoms and R is a straight or branched-chain alkyl group with 1-6 C atoms or benzyl. The process is characterized in that a racemic bicyclooctandione of formula (U)-II, where A, B and R have the above notations, is treated with rhizopus-, rhodotorula- or candida strains, and in the case that the strain used reduces the form (-)- from the racemate (U)-II, a chemical or microbiological reduction of the unmodified bicyclooctandion of formula (+)-II follows said treatment. |