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filingDate 1987-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8be42be288fd98c3341d6effa6e9ddb2
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publicationDate 1988-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-8800204-A2
titleOfInvention Polypeptide competitor for immunoglobulin e
abstract A competitor for human Immunoglobulin E (IgE) comprises a polypeptide which has a core sequence of seventy-six amino acids which is shown, together with the corresponding DNA sequence coding therefor, in Fig. 2. This amino acid sequence, numbered 1 to 76, corresponds to amino acids 301 to 376 of the epsilon heavy chain of IgE. The polypeptide may also include additional short sequences at the beginning and/or end of the core sequence which are physiologically harmless and do not contribute to the ability of the core sequence to bind compete with native IgE for the high-affinity receptor sites on human cells. The polypeptide is indicated for the treatment of Type I hypersensitivity reactions such as hay fever. The polypeptide may be produced synthetically or by expression from Escherichia coli containing a plasmid having a DNA segment coding for the polypeptide.
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priorityDate 1986-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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