| abstract |
Compounds represented by general formula (I), where R2, R3 and R4 are each selected from the group consisting of H, and OA; A is H or formula (II); R5 is selected from the group consisting of alkyl and aromatic residues; n is 2 or 3; and R1 is selected from the group consisting of (a), (b), (c) and (d) wherein R6 is selected from the group consisting of halogen, hydrocarbyl and hetero atom-substituted hydrocarbyl, comprising from 1 to 12 carbon atoms and wherein said hetero-atoms are selected from the group consisting of halogen, nitrogen, oxygen, sulfur and phosphorus; R7 is R6 or H and m equals 1, 2 or 3; with the proviso that at least one of R2, R3 and R4 is H, that at least one of R2, R3 and R4 is not H and that R2 and R4 are not both OA; and pharmaceutically-acceptable salts thereof. The compounds are dopamine receptor agonists and useful for the treatment of glaucoma in mammals. |