| abstract |
Method for stimulating angiogenesis in a mammal, characterized by the use of a modulator of collagen sysnthesis or of collagen fibril assembly. Preferably the modulator is an inhibitor of the enzyme proline hydroxylase. Preferably the modulator is selected from the group which includes cis-4-hydroxy-L-proline, 3,4-dehydro-L-proline, L-azetidine-2-carboxylic acid, L-proline analogues, and their pharmacologically active analogues and derivatives. The modulator may optionally be used together with a second stimulator of angiogenesis. Compositions containing said modulators are also claimed. |