http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-8704713-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f4ebdc9014596949540141ccb5a73064 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1b0c198757da18cf77dfbdcef00abb70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f284063f104b8b8f8758329c12c8d84e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 |
| filingDate | 1987-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_171147d412cdccb10d916c573fcd0266 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d406594bf32fe1771623c80cdd0c93f6 |
| publicationDate | 1987-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-8704713-A3 |
| titleOfInvention | Monitoring method for the synthesis of a linear combination of amino acid residues |
| abstract | Monitoring method which finds particular (but not exclusive) application in solid phase peptide synthesis. In one aspect, the synthesis starts with an amino acid residue protected by an N-alpha-amino protecting group and involves the steps: (a) removing the N-alpha-amino protecting group to obtain an N-alpha-amino group, (b) adding an amino acid residue protected by an N-alpha-amino protecting group, via a peptide bond, to the N-alpha-amino group obtained in step (a) by use of a reactive protected amino acid derivative and, where necessary, a catalyst, and (c) repeating steps (a) and (b) until the desired linear combination has been obtained; the reaction system includes 3-hydroxy-1,2,3-benzotriazin-4(3H)-one or a derivative thereof; and the colour of the reaction system or of a component thereof is monitored during the synthesis. The solvent is preferably a polar aprotic solvent, e.g. dimethylformamide. Where the synthesis is a solid phase synthesis, the solid phase is preferably a polyamide. Apparatus for carrying out these methods is also disclosed. In a preferred embodiment, this apparatus comprises (i) a column for receiving particles including a polyamide resin on which the solid phase synthesis is to take place; (ii) a light source disposed on one side of said column; (iii) a focussing arrangement disposed adjacent said column and opposite said light source; (iv) a photometer positioned to receive light focussed by said focussing arrangement; and (v) a microprocessor programmed to respond to the output of said photodetector and to control the synthesis procedure in response thereto. |
| priorityDate | 1986-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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