abstract |
Novel renin-inhibiting peptides of the formula X-A6-B5-C8-D9-E10-F11-G12-H13-I14-Z, wherein X and Z are terminal groups, C8 contains S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid, and 3-(arylthio)alkyl moieties, and the remaining variables are amino acid residues. Such inhibitors are useful for the diagnosis and control of renin-dependent hypertension. |