| abstract |
Pyridopyrimidine nucleotide derivatives represented by general formula (I), (wherein X1 and Y1 each represents formula (II), (wherein n represents an integer of 0, 1, 2 or 3 provided that n in X1 and in Y1 do not represent 0 at the same time), Z represents a hydrogen atom or formula (III), (wherein m represents an integer of 0, 1, 2 or 3), W1 represents a hydrogen atom or a hydroxy group, R2 represents a single bond between the 7-position carbon atom and the 8-position nitrogen atom when R1 represents an amino group or halogen, and R1 represents a carbonyl bond ($(1,3)$C=O) together with the 7-position carbon atom when R2 represents hydrogen or a lower alkyl group) and oligo- or polynucleotides containing at least one such moiety within, or at a terminal of, the molecule are disclosed. They are fluorescent and can form a base pair with guanidine or adenine. |