| abstract |
Antibiotic 10381a1, wherein R is hydrogen, is a cytosine-containing antibiotic producible by culturing Streptomyces arginensis in an aqueous medium and isolation thereof. Derivatives wherein R is a C1 to C3 alkyl ester of antibiotic 10381a1, are also disclosed along with the pharmaceutically acceptable salts of both the native and esterified forms. The compounds inhibit the growth of selected species of yeast, fungi and bacteria. |