http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-8604234-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac40ffdd0f9b7563bab9d5dccaa8a6b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f269feab0481eefe6a3fc8fa8d20471b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_464b492f4c2fdb4ba994a5c1e3b462f8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-557 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-175 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-0091 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C325-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-557 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C239-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C337-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C281-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C313-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-175 |
| filingDate | 1986-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34453ee9608725fc8db1f843fc4f243b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_126f29d4fd51349f39c91d911dcd020b |
| publicationDate | 1986-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-8604234-A3 |
| titleOfInvention | Thromboxane antagonists in the treatment of hormone-dependent neoplasias |
| abstract | Compounds having thromboxane antagonist activity are of use in the treatment of hormone-dependent neoplasias for example oestrogen-dependent neoplasias. Thromboxane antagonists of particular value are compounds of formula (I) wherein formula (II) represents one of the divalent cyclic groups (III). The letters a and b indicating in each case the points of attachment of the substituents R1 and CV(R2)-NV'R, respectively; R1 is a 6-carboxyhex-2-enyl group or a modification thereof in which the group is altered by one, or an appropriate combination of two or more, of the following: (a) alteration of the position of the double bond, (b) reduction of the double bond, (c) alteration of the chain length through a decrease of one or two methylene groups or an increase of one to six methylene groups, (d) replacement of one or two methylene groups each separately by an oxygen or sulphur atom with the proviso that in the modified group no oxygen or sulphur atom is in an alpha position relative to either a doubly bonded carbon atom or to the carboxy group or a derivative thereof and that at least 2 carbon atoms separate any pair of oxygen and/or sulphur atoms; and (e) formation of an amide, ester or salt derivative of the carboxy groups; V and V' either each separately is hydrogen or together are the second bond of a carbon-nitrogen double bond; R2 is hydrogen, an aliphatic hydrocarbon group or an aliphatic hydrocarbon group substituted by an aromatic group directly or through an oxygen or sulphur atom; and R is a group -NH.CO.NH-R3 or -NH.CS.NH-R3 wherein R3 is an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by one or more aromatic groups directly or through an oxygen or sulphur atom. |
| priorityDate | 1985-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.