| abstract |
Novel fused 7-membered ring compounds of formula (I), wherein R1 and R2 each represent H, halogen, CF3, lower alkyl, lower alkoxy or R1 and R2 are combined together to represent tri- or tetra-methylene, R3 represents H or optionally substituted lower alkyl or aralkyl, R4 represents H or optionally substituted alkyl, aralkyl or cycloalkyl, Y represents optionally esterified or amidated carboxyl, and m represents 1 or 2, and salts thereof. The compounds and their salts are effective in inhibiting an angiotensin-converting enzyme, and are useful for diagnosis, prophylaxis or treatment of circulatory diseases such as hypertension, heart disease, and apoplexy. |