| abstract |
Compounds of formula (I), wherein: R1? is H, OH, -OCH3?, -CH2?OH, -NH2?, -NHCH3?, -NHCH2?CH3?, -N(CH3?)2?, -N(CH2?CH3?)2?, formulas (II), (III), halogen, or formula (IV), wherein R2? is H, -CH3?, or formula (V), wherein R3? is phenyl, benzyl, or 1-4 carbon alkyl; R4? is H, -CH3?, -CH2?OH, -CH2?-CN, -CH2?-S-CH3?, -CH2?-S-CN, or formula (VI), wherein R5? is H, 1-4 carbon alkyl, alkenyl, or alkynyl, or aralkyl having a 1-4 carbon alkylene moiety, propargyl, 2-thienylethyl or 3-thienylethyl, provided that when R4? is H or -CH3?, R5? is propargyl, 2-thienylethyl or 3-thienylethyl; A is -CH2?- or -CH2?CH2?, their preparation, pharmaceutical compositions containing them and their use as dopamine agonists. |