| abstract |
Cephalosporin compounds represented by the general formula (I), wherein R1 represents alkyl, alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylmethyl, or substituted or unsubstituted phenoxymethyl, and R2 represents carboxyl or protected carboxyl, are prepared in a high yield with a high purity by reacting a thiazolinoazetidinone derivative represented by the general formula (II), with successively, a nucleophilic agent, a sulfur-containing compound, and ammonia. |