| abstract |
4-cyano-2-azetidinone derivates s represented by the following general formula:$(8,)$ wherein R1 represents an amino group which may be acylated or protected, X represents H or a methoxy group, and W represents H or a sulfo group, and a process for their preparation shown by the following scheme $(15,)$ (wherein R2 represents an amino group which may be acylated or protected, Y represents halogen or a group represented by$(6,)$(wherein R3 represents a hydrocarbyl group, and n represents 1 or 2), R4 represents an amino group which may be acylated or protected, and other symbols are the same as defined above). Compounds (I) are utilized as advantageous intermediates for synthesizing optically active 4-substituted-2-azetidinone derivatives, and compounds (I) wherein W = SO3H are utilized as bactericides and beta-lactamase inhibitors. |