| abstract |
A new and significantly improved type of lipid vesicle, called stable pluralilamellar vesicle (SPLV), and its manufacturing process, comprises the formation of a dispersion of at least one amphipathic lipid, such as phosphatidylcholine, in an organic solvent, combining the dispersion with a sufficient amount of an aqueous phase to form a double phase mixture where the aqueous phase can be fully emulsified, and emulsifying the aqueous phase and evaporating the organic solvent from the double phase mixture . SPLVs are stable during storage and can be used in vivo to release compounds continuously and in the treatment of diseases. |